Engineer I - Upstream Bio-Process
Company: Amgen
Location: Thousand Oaks
Posted on: June 27, 2025
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Job Description:
Join Amgens Mission of Serving Patients At Amgen, if you feel
like youre part of something bigger, its because you are. Our
shared missionto serve patients living with serious illnessesdrives
all that we do. Since 1980, weve helped pioneer the world of
biotech in our fight against the worlds toughest diseases. With our
focus on four therapeutic areas Oncology, Inflammation, General
Medicine, and Rare Disease we reach millions of patients each year.
As a member of the Amgen team, youll help make a lasting impact on
the lives of patients as we research, manufacture, and deliver
innovative medicines to help people live longer, fuller happier
lives. Our award-winning culture is collaborative, innovative, and
science based. If you have a passion for challenges and the
opportunities that lay within them, youll thrive as part of the
Amgen team. Join us and transform the lives of patients while
transforming your career. Engineer I - Upstream Bio-Process What
you will do Lets do this. Lets change the world. In this vital role
you will support technology transfer and process validation for
human therapeutic products (biological drug substance) across the
clinical and commercial manufacturing space. Responsibilities:
Transfer cell culture/purification drug substance processes and
perform process improvements from the laboratory into the
manufacturing facility and between manufacturing sites Provide
process validation support for late stage commercial processes
Provide on-the-floor technical support for successful scale-up and
transfer of process technology, and for clinical or commercial
manufacturing operations Provide routine process monitoring and
troubleshooting Perform data trending and statistical process
analysis Provide technical contributions for process related
deviations (NCs), CAPAs and change controls Identify and support
process related operational excellence opportunities Represent
process development and collaborate with other functions such as
Manufacturing, Quality, and Regulatory What we expect of you We are
all different, yet we all use our unique contributions to serve
patients. The dynamic professional we seek is an individual with
these qualifications. Basic Qualifications: Masters degree Or
Bachelors degree and 2 years of Process Development experience Or
Associates degree and 6 years of Process Development experience Or
High school diploma / GED and 8 years of Process Development
experience Preferred Qualifications: Masters degree in
Chemical/Biochemical Engineering or related subject area 3 years of
experience in Process Engineering related to biochemical
engineering and/or protein biochemistry, scale-up principles and
manufacturing of biologics (cGMP) Upstream and/or Downstream
process knowledge and hands on cell culture and/or purification
pilot/clinical/commercial experience with regard to the manufacture
of a biological drug substance Experience working in/supporting a
commercial cGMP manufacturing facility A firm understanding of cell
culture process and related equipment; scale-up from bench to
commercial scale, mass oxygen transfer capabilities, metabolism
profiling, influence of raw material attributes and impact of
process deviations to growth and quality attributes Knowledge of
aseptic processing/techniques, harvest and clarification processes
used in mammalian cell culture processes AND/OR a good
understanding of purification process and associated equipment;
chromatography, ultrafiltration, normal flow filtration, virus
inactivation and virus filtration operations Process development
(PD) experience supporting cGMP manufacturing at large scale Strong
capability in scientific/engineering/laboratory analysis,
troubleshooting and ability to apply sophisticated problem
resolution abilities Ability to develop and follow detailed
protocols Independently motivated with ability to multi-task and
work in teams Excellent written and verbal communication with
experience with technical writing and presentations What you can
expect from us As we work to develop treatments that take care of
others, we also work to care for your professional and personal
growth and well-being. From our competitive benefits to our
collaborative culture, well support your journey every step of the
way. The expected annual salary range for this role in the U.S.
(excluding Puerto Rico) is posted. Actual salary will vary based on
several factors including but not limited to, relevant skills,
experience, and qualifications. In addition to the base salary,
Amgen offers a Total Rewards Plan, based on eligibility, comprising
of health and welfare plans for staff and eligible dependents,
financial plans with opportunities to save towards retirement or
other goals, work/life balance, and career development
opportunities that may include: A comprehensive employee benefits
package, including a Retirement and Savings Plan with generous
company contributions, group medical, dental and vision coverage,
life and disability insurance, and flexible spending accounts A
discretionary annual bonus program, or for field sales
representatives, a sales-based incentive plan Stock-based long-term
incentives Award-winning time-off plans Flexible work models,
including remote and hybrid work arrangements, where possible Apply
now and make a lasting impact with the Amgen team.
careers.amgen.com In any materials you submit, you may redact or
remove age-identifying information such as age, date of birth, or
dates of school attendance or graduation. You will not be penalized
for redacting or removing this information. Application deadline
Amgen does not have an application deadline for this position; we
will continue accepting applications until we receive a sufficient
number or select a candidate for the position. As an organization
dedicated to improving the quality of life for people around the
world, Amgen fosters an inclusive environment of diverse, ethical,
committed and highly accomplished people who respect each other and
live the Amgen values to continue advancing science to serve
patients. Together, we compete in the fight against serious
disease. Amgen is an Equal Opportunity employer and will consider
all qualified applicants for employment without regard to race,
color, religion, sex, sexual orientation, gender identity, national
origin, protected veteran status, disability status, or any other
basis protected by applicable law. We will ensure that individuals
with disabilities are provided reasonable accommodation to
participate in the job application or interview process, to perform
essential job functions, and to receive other benefits and
privileges of employment. Please contact us to request
accommodation. Amgen is an Equal Opportunity employer and will
consider you without regard to your race, color, religion, sex,
sexual orientation, gender identity, national origin, protected
veteran status, or disability status.
Keywords: Amgen, Los Angeles , Engineer I - Upstream Bio-Process, Engineering , Thousand Oaks, California
